Scientific Publications
The following manuscripts, editorials and abstracts have been published by Dr. Egan and his collaborators at UNC or at Lung Banks of America.
Published Manuscripts
Venkataraman A, Blackwell JW, Funkhouser WK, Birchard KR, Beamer SE, Simmons WT, et al. Beware Cold Agglutinins in Organ Donors! Ex Vivo Lung Perfusion From an Uncontrolled Donation After Circulatory-Determination-of-Death Donor With a Cold Agglutinin: A Case Report. Transplantation proceedings. 2017;49(7):1678-81. doi: 10.1016/j.transproceed.2017.04.004. PubMed PMID: 28838463.
Egan TM, Requard JJ. Uncontrolled donation after circulatory determination of death donors (uDCDDs) as a source of lungs for transplant. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2015 15(8):2031-6. Epub April 14, 2015. PubMed PMID: 25873272.
Burker EJ, Fingerhut D, Ebneter D, Giza M, Espey Weber R, Noone PG, et al. Emergency medical services knowledge and attitudes about non-heart-beating donors: Effect of an educational intervention. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2015;34(2):204-12. doi: 10.1016/j.healun.2014.09.020. PubMed PMID: 25447576.
Dong B, Stewart PW, Egan TM. Postmortem and ex vivo carbon monoxide ventilation reduces injury in rat lungs transplanted from non-heart-beating donors. The Journal of thoracic and cardiovascular surgery. 2013;146(2):429-36 e1. doi: 10.1016/j.jtcvs.2012.11.005. PubMed PMID: 23260460.
Casiraghi M, Tatreau JR, Abano JB, Blackwell JW, Watson L, Burridge K, et al. In vitro modeling of non-hypoxic cold ischemia-reperfusion simulating lung transplantation. The Journal of thoracic and cardiovascular surgery. 2009;138(3):760-7. PubMed Central PMCID: PMC2760451.
Inokawa H, Sevala M, Funkhouser WK, Egan TM. Ex-vivo perfusion and ventilation of rat lungs from non-heart-beating donors before transplant. The Annals of thoracic surgery. 2006;82(4):1219-25.
Takashima S, Koukoulis G, Inokawa H, Sevala M, Egan TM. Inhaled nitric oxide reduces ischemia-reperfusion injury in rat lungs from non-heart-beating donors. The Journal of thoracic and cardiovascular surgery. 2006;132(1):132-9.
Egan TM, Hoffmann SC, Sevala M, Sadoff JD, Schlidt SA. Nitroglycerin reperfusion reduces ischemia-reperfusion injury in non-heart-beating donor lungs. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2006;25(1):110-9.
Egan TM, Haithcock JA, Nicotra WA, Koukoulis G, Inokawa H, Sevala M, et al. Ex-vivo evaluation of human lungs for transplant suitability. The Annals of thoracic surgery. 2006;81(4):1205-13.
Takashima S, Schlidt SA, Koukoulis G, Sevala M, Egan TM. Isoproterenol reduces ischemia-reperfusion lung injury despite beta-blockade. The Journal of surgical research. 2005;126(1):114-20. Epub 2005/05/27. doi: 10.1016/j.jss.2005.01.017. PubMed PMID: 15916984.
Koukoulis G, Caldwell R, Inokawa H, Button B, Sevala M, Lyles JD, et al. Trends in lung pH and PO2 after circulatory arrest: implications for non-heart-beating donors and cell culture models of lung ischemia-reperfusion injury. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2005;24(12):2218-25. PubMed PMID: 16364874.
Egan TM, Thomas Y, Gibson D, Funkhouser W, Ciriaco P, Kiser A, et al. Trigger for intercellular adhesion molecule-1 expression in rat lungs transplanted from non-heart-beating donors. The Annals of thoracic surgery. 2004;77(3):1048-55; discussion 55. Epub 2004/03/03. doi: 10.1016/j.athoracsur.2003.08.023. PubMed PMID: 14992925.
Egan TM. Non-heart-beating donors in thoracic transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2004;23(1):3-10. Epub 2004/01/22. PubMed PMID: 14734121.
Kiser AC, Ciriaco P, Hoffmann SC, Egan TM. Lung retrieval from non-heart beating cadavers with the use of a rat lung transplant model. The Journal of thoracic and cardiovascular surgery. 2001;122(1):18-23. Epub 2001/07/04. doi: 10.1067/mtc.2001.114634. PubMed PMID: 11436032.
Bleiweis MS, Jones DR, Hoffmann SC, Becker RM, Egan TM. Reduced ischemia-reperfusion injury with rolipram in rat cadaver lung donors: effect of cyclic adenosine monophosphate. The Annals of thoracic surgery. 1999;67(1):194-9; discussion 9-200. Epub 1999/03/23. PubMed PMID: 10086548.
Jones DR, Hoffmann SC, Sellars M, Egan TM. Reduced ischemia-reperfusion injury with isoproterenol in non-heart-beating donor lungs. The Journal of surgical research. 1997;69:385-92.
Jones DR, Becker RM, Hoffmann SC, Lemasters JJ, Egan TM. When does the lung die? Kfc, cell viability, and adenine nucleotide changes in the circulation-arrested rat lung. Journal of applied physiology (Bethesda, Md : 1985). 1997;83(1):247-52. Epub 1997/07/01. PubMed PMID: 9216970.
D’Armini AM, Lemasters JJ, Egan TM, Vigano M. Effect of perfusion pH on rat lung viability of non-heart beating donors. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 1997;12(5):787-91. Epub 1998/02/11. PubMed PMID: 9458152.
Roberts CS, Hennington MH, D’Armini AM, Griffith PK, Lemasters JJ, Egan TM. Donor lungs from ventilated cadavers: impact of a free radical scavenger. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 1996;15(3):275-82. Epub 1996/03/01. PubMed PMID: 8777211.
Roberts CS, D’Armini AM, Egan TM. Canine double-lung transplantation with cadaveric donors. The Journal of thoracic and cardiovascular surgery. 1996;112(3):577-83. Epub 1996/09/01. PubMed PMID: 8800142.
Hennington MH, D’Armini AM, Lemasters JJ, Egan TM. Cadaver lungs for transplantation: effect of ventilation with alveolar gas. Transplantation. 1996;61:1009-14.
D’Armini AM, Roberts CS, Lemasters JJ, Egan TM. Lung retrieval from cadaver donors with nonbeating hearts: optimal preservation solution. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 1996;15:496-505.
D’Armini AM, Lemasters JJ, Egan TM. Studies of rat lung viability and adenine nucleotide metabolism after death. The Annals of thoracic surgery. 1996;62:1448-53.
D’Armini AM, Tom EJ, Roberts CS, Henke DC, Lemasters JJ, Egan TM. When does the lung die? Time course of high energy phosphate depletion and relationship to lung viability after “death”. The Journal of surgical research. 1995;59:468-74.
D’Armini AM, Roberts CS, Griffith PK, Lemasters JJ, Egan TM. When does the lung die? I. Histochemical evidence of pulmonary viability after “death”. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 1994;13:741-7.
Alessandrini F, D’Armini AM, Roberts CS, Reddick RL, Egan TM. When does the lung die? II. Ultrastructural evidence of pulmonary viability after “death”. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 1994;13(5):748-57. PubMed PMID: 7803414.
Ulicny Jr KS, Egan TM, Lambert Jr CJ, Reddick RL, Wilcox BR. Cadaver lung donors: effect of preharvest ventilation on graft function. The Annals of thoracic surgery. 1993;55:1185-91.
Egan TM, Ulicny KS, Jr., Lambert CJ, Jr., Wilcox BR. Effect of a free radical scavenger on cadaver lung transplantation. The Annals of thoracic surgery. 1993;55(6):1453-9. Epub 1993/06/01. PubMed PMID: 8512395.
Egan TM, Lambert CJ, Jr., Reddick R, Ulicny KS, Jr., Keagy BA, Wilcox BR. A strategy to increase the donor pool: use of cadaver lungs for transplantation. The Annals of thoracic surgery. 1991;52(5):1113-20; discussion 20-1. Epub 1991/11/11. PubMed PMID: 1953132.
Invited Editorials
Egan TM. Lung Transplant From an Uncontrolled Donation After Circulatory Determination of Death Donor: Moving to Other Countries. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2016;16(4):1051-2. doi: 10.1111/ajt.13658. PubMed PMID: 26696013.
Egan TM. Non-heart-beating lung donors: yes or no? The Annals of thoracic surgery. 2000;70(5):1451-2. Epub 2000/11/28. PubMed PMID: 11093467.
Published Abstracts
Egan TM, Blackwell J, Haithcock B, Long J, Birchard K, Lobo J, et al. Lessons learned from the first clinical trial to compare outcomes of lungs transplanted from uncontrolled Donation after Circulatory Determination of Death donors (uDCDDs) assessed by ex-vivo lung perfusion (EVLP) and CT scan and lungs transplanted from conventional donors (CONV) (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2017 36(4S):S145.
Masuodi S, Blackwell J, Stewart P, Egan TM. Cytokine levels in Steen Solution perfusate increase during ex-vivo lung perfusion (EVLP) of lungs from conventional donors (Conv) and uncontrolled Donation after Circulatory Determination of Death donors (uDCDDs) (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2017;36(4S):S311.
Egan TM, Requard JJ, Edwards TP. What does first person authorization (FPA) mean? Knowledge and attitudes among FPA adults re: Brain Dead donors (BDDs) and controlled Donation after Circulatory Determination of Death (cDCDD) donors. Understanding vs the law (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2017;36(4S):S177.
Egan TM, Requard III J, Edwards T. Can lungs be recovered quickly from first person authorized (FPA) uncontrolled Donation after Circulatory Determination of Death donors (uDCDDs)? The law vs knowledge and attitudes among FPA adults (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2017;36(4S):S284.
Egan T, Blackwell J, Birchard K, Haithcock B, Long J, Gazda S, et al. Assessment of lungs for transplant recovered from uncontrolled Donation after Circulatory Determination of Death Donors (uDCDDs) (Abstract). Ann Am Thorac Soc. 2017;14(Supplement 3):S251. doi: 10.1513/AnnalsATS.201609-687MG.; PubMed Central PMCID: PMC28945476.
Egan TM, Requard JJ, Stewart P, Thys C. Obstacles to lung transplant from uncontrolled donation after circulatory determination of death donors (uDDCDDs) (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2016;35 (4S):S66.
Egan TM, Haithcock B, Long J, Birchard K, Lobo J, Stewart P, et al. Interim results of a Phase II clinical trial comparing outcomes of recipients of lungs recovered from uncontrolled donation after circulatory determination of death donors (uDCDDs) assessed by ex-vivo lung perfusion (EVLP) and CT scan to outcomes of recipients of lungs from brain-dead donors (BDDs). (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2016;35(4S):S372.
Egan TM, Requard JJ, Gazda S, Casey N. Health of potential uncontrolled Donation after Circulatory Determination of Death (uDCDD) lung donors: Impact on the size of the uDCDD donor pool (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2015;34 (4S):S281.
Egan TM, Dong B, Blackwell J, Birchard K, Stewart P, Funkhouser W, et al. Assessing human lungs unsuitable for transplant by ex-vivo lung perfusion (EVLP) and ex-vivo CT scan; Does EVLP cause inflammation? (Abstract) The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2015;34 (4S):S139.
Egan TM, Blackwell J, Gazda S, Forrest L, Haithcock B, Long J, et al. Assessment of human lungs recovered from uncontrolled Donation after Circulatory Determination of Death (uDCDD) donors by ex-vivo lung perfusion (EVLP) and CT scan (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2015;34 (4S):S247.
Egan TM, Gazda S, Stewart P. If I had a million lungs: Impact of uncontrolled donation after cardiac death donors (uDCDDs) on the number of potential lung donors in the U.S. (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2014;33(4):S47.
Egan TM, Blackwell J, Forrest L, Gazda S, Requard JJ, Haithcock B, et al. Evaluation of human lungs from uncontrolled donation after cardiac death donors (uDCDDs) with ex-vivo lung perfusion (EVLP) (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2014;33(4):S47.
Egan T, Haithcock B, Long J, Noone P, Blackwell J, Forrest L, et al. Preliminary results of a Phase II trial comparing outcomes of patients transplanted with lungs from uncontrolled donation after cardiac death donors (uDCDDs) assessed with ex-vivo lung perfusion (EVLP) to lungs from conventional brain-dead donors (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2014;33(4):S17.
Egan T, Burker E, Requard JJ, Noone P, Murray G. Challenges to lung recovery from sudden death victims to assess suitability for transplant, and strategies to address these challenges (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2014;33(4):S227.
Egan T, Blackwell J, Forrest L, Simmons W, Birchard K, Funkhouser W, et al. Evaluation of human lungs from category 1 non-heart-beating donors (NHBDs) with ex-vivo lung perfusion (EVLP) in the U.S. (Abstract) Chest. 2014;145(3_MeetingAbstracts):635A.
Venkataraman A, Blackwell J, Simmons W, Beamer S, Forrest L, Randell S, et al. Beware cold agglutinins in organ donors: Ex-vivo lung perfusion (EVLP) of lungs from a Category 1 non-heart-beating donor (NHBD) with a cold agglutinin. (Abstract) International Society for Heart and Lung Transplantation, Montreal, April 24, 2013 2013. Available from: http://tinyurl.com/prbq49m.
Egan T, Dong B, Tikunov A, Semelka C, Kuan P-F, Macdonald J. Metabolomic profile of rat lung tissue after death: Effect of delayed post-mortem O2-ventilation (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2013;32(4):S296-7.
Egan T, Dong B, Tikunov A, Semelka C, Blackwell J, Simmons W, et al. Effect of ex-vivo lung perfusion (EVLP) on metabolomics profile of human lungs (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2013;32(4):S247.
Egan T, Dong B, Blackwell J, Simmons W, Jernigan E, Nicotra W, et al. Ex-vivo lung perfusion (EVLP) of human lungs – a preclinical study to assess transplant suitability (Abstract). Chest. 2011;140 (4_Meeting Abstracts;841A):doi: 10.1378/chest.1117602. URL: http://journal.publications.chestnet.org/article.aspx?articleid=046047.
Dong B, Egan T. Post-mortem and ex-vivo carbon monoxide (CO) ventilation reduces ischemia-reperfusion injury (IRI) in rat lungs transplanted from non-heart-beating donors (NHBDs) (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2010;29 (2S):S95.
Dong B, Egan T. Nitric oxide (NO) ventilation of rat lungs before and after retrieval from non-heart-beating donors (NHBDs) reduces vascular resistance (PVR) and ischemia-reperfusion injury (IRI) after transplant (tx) [Abstract] Am J Resp Crit Care Med. 2008;177:A307.
Dong B, Egan T. Post-mortem and ex-vivo nitric oxide (NO) ventilation reduces ischemia-reperfusion injury (IRI) in rat lungs transpanted from non-heart-beating donors (NHBDs) [Abstract] The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2008;27(2S):S253.
Casiraghi M, Mendoza A, Blackwell J, Watson L, Tatreau J, Sevala M, et al. Non-hypoxic ischemia: An accurate cell culture model of ischemia reperfusion injury in lung transplantation (Abstract). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2007;26(2S):S79.
Koukoulis G, Yuan Y, Jin J, Egan T. Gene expression in transplanted rat lungs: conventional vs. non-heart beating donors (Abstract). Am J Resp Crit Care Med. 2004;169(7):A218.
Takashima S, Schlidt S, Koukoulis G, Egan T. Isoproterenol amelioriates ischemia-reperfusion lung injury (IRI) in rat lungs from non-heart-beating donors even with ß-blockade (Abstract). Am Jour Resp Crit Care Med. 2003;167(7):A363.
Takashima S, Koukoulis G, Egan T. Inhaled nitric oxide ameliorates ischemia-reperfusion injury in rat lungs from non-heart-beating donors (Abstract). Chest. 2003;124(4):201-2S.
Schlidt S, Takashima S, Koukoulis G, Egan T. Effect of combined cAMP and cGMP augmentation on IRI in lungs from non-heart-beating donors: synergy or competition? (Abstract). Chest. 2003;124(4):201S.
Koukoulis G, Caldwell R, Button B, Lyles J, Egan T. What happens to pH and pO2 in non-heart beating donor lungs after circulatory arrest? (Abstract). Am Jour Resp Crit Care Med. 2003;167(7):A363.
Egan T, Hoffmann S, Sadoff J. Reperfusion with nitroglycerin reduces ischemia-reperfusion injury in non-heart beating donor lungs (Abstract). Am J Resp Crit Care Med. 2002;165:B13.
Thomas YM, Paik HC, Hoffmann SC, Ciriaco P, Funkhouser WK, Bleiweis MS, et al. Are adhesion molecules upregulated after lung transplant from non-heart beating donors? (Abstract). Chest. 1998;114 (Suppl):398S.
Egan TM. Cadavers as lung donors: experience with experimental models (Abstract). Jap J Transplant. 1998;33:109.
Bleiweis MS, Jones DR, Hoffmann SC, Paik HC, Ciriaco P, Egan TM. Maintenance of cAMP improves lung endothelial integrity in cadaveric rat lungs (Abstract). Chest. 1998;114(Suppl):284S.
Jones DR, Becker RM, Lemasters JJ, Egan TM. Is pulmonary microvascular integrity maintained after death? (Abstract). Chest. 1996;110:221S.
Hennington MH, Egan TM. Cadaver lungs for transplantation: effect of ventilation with alveolar gas. Chest. 1992;102(Suppl):79S.
Ulicny Jr KS, Egan TM, Lambert Jr CJ, Wilcox BR. Postmortem nitrogen ventilation improves function of transplanted canine cadaver lungs. Chest. 1991;100(Suppl):63S.